. Author manuscript; available in PMC: 2016 Jun 16.

Published in final edited form as: Sci Transl Med. 2015 Jul 15;7(296):296ra112. doi: 10.1126/scitranslmed.aab4005

Table 2. Interactions of HLA class II alleles and vaccine-induced responses have an independent effect on HIV-1 acquisition.

ORs for HIV-1 acquisition in a multivariable analysis of all primary immune response variables from the immune correlate study (3) and the two significant HLA interactions observed in this study.

Variable	Multivariable model^*
Variable	OR (95% CI)	P value
Avidity of IgG antibodies for Env	0.94 (0.56–1.57)	0.80
ADCC	0.97 (0.62–1.51)	0.89
Neutralizing antibodies	1.08 (0.63–1.85)	0.78
Env-specific CD4⁺ T cells	1.07 (0.77–1.50)	0.68
Env-specific IgA-DQB1*06 interaction^†	8.24 (2.07–32.75)	0.003
Env (120–204)–specific IgG-DPB1*13 interaction^†	0.27 (0.09–0.80)	0.02

For each primary immune variable (3), the OR is reported per 1-SD increase; sex, baseline behavioral risk score, and one significant principal component axis were included as covariates in the model. Env-specific IgA, DQB1*06, Env (120–204)–specific IgG, and DPB1*13 were also included as main effects.

^†

Reported ORs and 95% CIs reflect the results from logistic regression analysis including a two-way interaction term for Env-specific IgA or Env (120–204)–specific IgG and the absence or presence of the given allele.