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. 2016 Jun 16;11(6):e0157368. doi: 10.1371/journal.pone.0157368

Table 2. Gene ontology analysis of differentially expressed genes between tumor epithelial and stromal cell.

Gene ontology pathways enriched in tumor epithelium
Gene Set Name Description # Genes in overlap FDR q-value
Reactome cell cycle Genes involved in Cell Cycle 21 1.21E-14
Reactome cell cycle mitotic Genes involved in Cell Cycle, Mitotic 19 1.28E-14
Reactome mitotic M G1 Genes involved in Mitotic M-M/G1 phases 13 4.38E-11
Reactome DNA replication Genes involved in DNA Replication 13 1.35E-10
KEGG cell cycle Cell cycle 10 1.44E-08
Reactome cell cycle checkpoints Genes involved in Cell Cycle Checkpoints 9 2.17E-07
Reactome mitotic prometaphase Genes involved in Mitotic Prometaphase 8 2.45E-07
Reactome mitotic G1/S phases Genes involved in Mitotic G1-G1/S phases 9 3.95E-07
Reactome g1 s transition Genes involved in G1/S Transition 8 1.44E-06
PID plk1 pathway PLK1 signaling events 6 2.49E-06
Gene ontology pathways enriched in tumor stoma
Gene Set Name Description # Genes in overlap FDR q-value
NABA matrisome Genes encoding ECM proteins 22 2.32E-16
NABA core matrisome Core ECM glycoproteins and collagens 14 6.39E-15
NABA proteoglycans Genes encoding proteoglycans 5 1.06E-06
Reactome collagen formation Genes involved in Collagen formation 5 1.09E-05
PID integrin1 pathway Beta1 integrin cell surface interactions 5 1.68E-05
PID avb3 integrin pathway Integrins in angiogenesis 5 2.68E-05
Reactome extracellular matrix Genes involved in ECM organization 5 4.85E-05
NABA collagens Genes encoding collagen proteins 4 1.13E-04
PID syndecan 1 pathway Syndecan-1-mediated signaling events 4 1.20E-04
KEGG melanoma Melanoma 4 6.25E-04