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. 2016 Jun 16;11(6):e0157397. doi: 10.1371/journal.pone.0157397

Fig 2. Analysis of src and downstream signalling in response to dasatinib combined with endocrine agents.

Fig 2

Wt-MCF7, MCF7-LTED, 1%MCF7 and MCF7-TAMR cells were treated for 24-hours with the drug combinations mentioned above. Standard concentrations of dasatinib (100nM), E2 (0.01nM), 4-OHT (10nM) and fulvestrant (ICI) (10nM) were used. Whole-cell extracts were assessed for expression of various proteins indicated using immunoblotting. Figures below each panel represent semi-quantitave changes in protein expression relative to actin.