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. 2016 Jun 16;11(6):e0157748. doi: 10.1371/journal.pone.0157748

Fig 2. Inhibition of CCR3 effectively reduces CNV in the laser-induced model.

Fig 2

Six-eight week old C57Bl/6 mice were lasered and administered 1 μL intravitreal CCR3i (10 μg/μl) or DMSO: (A) and (B) CNV volumes calculated 7 days after laser in isolectin stained RPE/choroidal flatmounts (Mag, 20X; Scale bar, 50 μm) (A, representative flatmount images and B, quantification of CNV volume; n = 40 spots/ group; **p<0.01 vs. DMSO treated eyes). (C) and (D) Lesion widths (red caliper) calculated 3 and 7 days after laser injury in DMSO and CCR3i groups (C, representative flat mount images and D, quantification of lesion width; n = 20–24 lesions/data point;**p<0.01 vs. day 7 DMSO).