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. 2016 Jun 16;11(6):e0157887. doi: 10.1371/journal.pone.0157887

Table 3. Viral RNA loads in respiratory tract tissues.

i.n. high dose i.n. low dose i.t. i.a.
Tissue 5 7 11 14 5 7 11 14 5 7 11 14 5 7 11 14
NC ++ +++ (+) + + + - + (+) (+) - - - +++ (+) (+)
Tonsil - (+) - - - - - - +++ (+) - - + + - -
Larynx - - - - - - - - (+) - - (+) (+) - - (+)
Trachea (+) - - ND - - - - (+) - - - - (+) - -
Bronchus - - - - - - - - + - - - +++ ++ - -
U Lung - - - - - - - - (+) ++ - - + (+) + -
M Lung - - - - - - - - (+) (+) - - + ++ (+) -
L Lung - - - - - - - - + (+) - - ++ + - -

Load is expressed as M gene RNA copies per mg tissue. Values of ≤ 103 /mg were considered not significantly above background. +++ > 106; ++105–106; + 104–105; (+) 103–104;—<103 copies/mg. ND, not done. NC, nasal cavity; U upper; M middle; L lower lung lobe.