TABLE 1.
Summary of gene mutations in F344 rat large intestinal tumors.a
| Animal ID | Dx | Codon 12 |
Kras Codon13 |
Codon 61 |
Ctnnb1 Exon 2 |
Tp53 Exons 5–8 |
|---|---|---|---|---|---|---|
| 962 | Ads | wt | wt | wt | wt | wt |
| 1712 | Ads | wt | GGC->CGC (Gly->Arg) | wt | wt | wt |
| 1711 | Ads | wt | wt | wt | Codon 32 GAT->AAT (Asp->Asn) | wt |
| 1812 | Ads | wt | wt | wt | wt | wt |
| 1301 | Ads | wt | wt | wt | Codon 45 TCC->TTC (Ser->Phe) | wt |
| 1102 | Ads | wt | wt | wt | wt | wt |
| 1602 | Ads | wt | GGC->CGC (Gly->Arg) | wt | wt | wt |
| 1922 | Ads | wt | wt | wt | Codon 41 ACC->CCC (Thr->Pro) | wt |
| 1052 | Cas | wt | wt | CAA->CGA (Glu->Arg) | wt | wt |
| 1151 | Cas | GGT->GAT (Gly->Asp) | wt | wt | wt | wt |
| 1402 | Cas | wt | wt | wt | Codon 34 GGA->GAA (Gly->Glu) | wt |
| 1921 | Cas | wt | wt | wt | wt | wt |
Note: There were no Kras, Ctnnb1, and Tp53 point mutations within the four age-matched untreated colon tissue from F344 control rats.
a
F344 rats were treated ad libitum with Aloe vera non-decolorized whole leaf extract in drinking water for 2 years.
Abbreviations: Ads, adenoma; Cas, carcinoma; Dx, diagnosis; N, normal colonic mucosal epithelium; wt, wild type.