TABLE 3.

Comparison of incidence of point mutations within large intestinal tumors of F344 rats chronically exposed to Aloe vera non-decolorized whole leaf extract with human colorectal cancer^a and rodent models of chemically induced colon cancer.^b

Group	% Kras mutations	% Ctnnb1 mutations	% Tp53 mutations
Aloe vera non-decolorized whole leaf extract	33	33	0
Human colon cancer	40–60	15–26	50*
Azoxymethane	30–60	50–80	0
Heterocyclic amines	0–14	50–75	0

^*Fisher exact test, p < .008.

^aBos et al. 1987; Morin et al. 1997.

^bJacoby et al. 1991; Vivona et al. 1993; Dashwood et al. 1998; Takahashi et al. 1998; Takahashi and Wakabayashi 2004.