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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Trends Biochem Sci. 2016 Feb 11;41(4):311–323. doi: 10.1016/j.tibs.2016.01.003

Figure 3. Hsp90 enhances the heregulin-HER3 Signaling Cascade.

Figure 3

Heregulin binds to its receptor and launches growth-promoting signaling through the Erk (left), src (far left) and Akt (right) branches. Numerous high affinity partners for Hsp90 (white circle) exist along these pathways, indicating the long reach of Hsp90 in cancer signaling. These pathways can be blocked by Hsp90 inhibitors at each individual Hsp90 chaperoned step, leading to multitargeted cancer therapy.