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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Trends Biochem Sci. 2016 Feb 11;41(4):311–323. doi: 10.1016/j.tibs.2016.01.003

Table1.

Major HSP families in humans

Protein Function Co-chaperones1 Refs
Small HSP (Hsp27) Chaperone None [12]
HSP60 Chaperonin Hsp10 [7]
HSP70 Chaperone Hsp40, Grpe, Bag1, Bag3, Hip, Hop, CHIP [4, 10, 14]
HSP90 Chaperone P23, Aha1, Hop, FKBP51, FKBP52, Cyp40, Cdc37 [5, 17, 23, 34]
HSP110 Holdase, Co-chaperone None [11, 13]
1

These are the major HSPs induced by heat shock. Their roles in cancers of various morphologies have been reviewed previously[3]. Co-chaperones Hsp10, Hsp40, Grpe, Bag1, Bag3, Hip, Hop, CHIP, p23, Aha1FKBP51 and FKBP52, Cyp40 and Cdc37 facilitate interactions of the primary chaperone with client proteins.