Table 3. Derivation of candidate Sepsis Risk Score (SRS) and Severe Sepsis Risk Score (SSRS) models.
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| SEPSIS RISK SCORE (SRS) | SEVERE SEPSIS RISK SCORE (SSRS | |||||||||||
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SRS MODEL 1 (Demographics, Health Behaviors, and Chronic Medical Conditions) |
SRS MODEL 2 (Add Biomarkers) |
SSRS MODEL 1 (Demographics, Health Behaviors, and Chronic Medical Conditions) |
SSRS MODEL 2 (Add Biomarkers) |
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| Variable | HR (95% CI) | β | SRS Points† | HR (95% CI) | β | SRS Points† | HR (95% CI) | β | SSRS Points† | HR (95% CI) | β | SSRS Points† |
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| Demographics, Health Behaviors and Chronic Medical Conditions | ||||||||||||
| Chronic lung disease | 2.18 (1.92-2.48) | 0.78 | 5 | 2.09 (1.83-2.38) | 0.74 | 5 | 1.93 (1.65-2.25) | 0.66 | 2 | 1.84 (1.58-2.15) | 0.61 | 5 |
| Age ≥75 years | 1.94 (1.73-2.18) | 0.66 | 4 | 1.62 (1.44-1.83) | 0.48 | 3 | 2.23 (1.96-2.54) | 0.80 | 3 | 1.71 (1.50-1.97) | 0.54 | 4 |
| Peripheral Artery Disease | 1.66 (1.29-2.13) | 0.50 | 3 | 1.50 (1.17-1.93) | 0.41 | 3 | 1.57 (1.18-2.09) | 0.45 | 2 | 1.41 (1.06-1.87) | 0.34 | 3 |
| Diabetes | 1.56 (1.40-1.75) | 0.45 | 3 | 1.41 (1.25-1.58) | 0.34 | 2 | 1.74 (1.53-1.98) | 0.55 | 2 | 1.52 (1.33-1.73) | 0.42 | 3 |
| Tobacco use (current) | 1.56 (1.36-1.78) | 0.44 | 3 | 1.40 (1.22-1.61) | 0.34 | 2 | 1.48 (1.26-1.74) | 0.39 | 1 | 1.33 (1.13-1.57) | 0.29 | 2 |
| White Race | 1.45 (1.29-1.62) | 0.37 | 2 | 1.46 (1.31-1.64) | 0.38 | 3 | 1.34 (1.18-1.52) | 0.29 | 1 | 1.34 (1.17-1.52) | 0.29 | 2 |
| Stroke | 1.42 (1.20-1.69) | 0.35 | 2 | 1.30 (1.10-1.54) | 0.27 | 2 | 1.52 (1.26-1.83) | 0.42 | 2 | 1.36 (1.13-1.63) | 0.30 | 2 |
| Atrial Fibrillation | 1.39 (1.19-1.61) | 0.33 | 2 | 1.31 (1.12-1.52) | 0.27 | 2 | 1.42 (1.20-1.68) | 0.35 | 1 | 1.32 (1.11-1.56) | 0.28 | 2 |
| Coronary artery disease | 1.35 (1.19-1.53) | 0.30 | 2 | 1.25 (1.10-1.41) | 0.22 | 2 | 1.54 (1.34-1.76) | 0.43 | 2 | 1.37 (1.20-1.57) | 0.32 | 2 |
| Obesity | 1.34 (1.21-1.50) | 0.30 | 2 | 1.20 (1.07-1.34) | 0.18 | 1 | 1.38 (1.21-1.56) | 0.32 | 1 | 1.21 (1.06-1.38) | 0.19 | 1 |
| Hypertension | 1.31 (1.16-1.46) | 0.27 | 2 | 1.15 (1.02-1.29) | 0.14 | 1 | 1.36 (1.19-1.55) | 0.31 | 1 | 1.15 (1.00-1.31) | 0.14 | 1 |
| Deep Vein Thrombosis | 1.27 (1.05-1.54) | 0.24 | 1 | 1.20 (1.00-1.46) | 0.19 | 1 | 1.31 (1.06-1.63) | 0.27 | 1 | 1.23 (0.99-1.52) | 0.21 | 2 |
| Male Sex | 1.19 (1.07-1.32) | 0.17 | 1 | 1.23 (1.11-1.37) | 0.21 | 1 | 1.43 (1.27-1.62) | 0.36 | 1 | 1.49 (1.32-1.69) | 0.40 | 3 |
| Biomarkers | ||||||||||||
| hsCRP >3.0 mg/dL | 1.48 (1.32-1.65) | 0.39 | 3 | 1.50 (1.31-1.71) | 0.40 | 3 | ||||||
| Cystatin-C ≥1.11 mg/dL | 1.62 (1.43-1.84) | 0.48 | 3 | 1.94 (1.66-2.26) | 0.66 | 5 | ||||||
| eGFR (creatinine) | 1.15 (1.00-1.33) | 0.14 | 1 | 1.36 (1.15-1.59) | 0.30 | 2 | ||||||
| <60 mL/min/1.73m2 | ||||||||||||
| ACR ≥ 30 mcg/mg | 1.45 (1.27-1.64) | 0.37 | 3 | 1.45 (1.26-1.67) | 0.37 | 3 | ||||||
| TOTAL RISK SCORE POINTS | 32 | 38 | 20 | 45 | ||||||||
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†
Points calculated as the Cox regression β value divided by the smallest β coefficient and rounded to the nearest integer. Scoring system based on pooled estimates following multiple imputation. Total N = 29,696.