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. Author manuscript; available in PMC: 2016 Jun 16.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2016 Mar 30;9(1):95–115. doi: 10.1146/annurev-anchem-071015-041514

Figure 4.

Figure 4

T2ex magnetic resonance imaging (MRI). (a) The r2ex relaxivity plotted relative to the bound water lifetime for multiple Eu(III) chelates at 9.4-T magnetic field strength (solid line) shows that contrast agents with a moderately fast chemical exchange rate can generate a T2ex effect. A lower T2ex effect is generated at 0.54 T (dotted line). (b) Coronal images of mouse kidneys before and after IV injection of EuDOTA−, EuDOTA-(gly)4−, and EuTETA− show that the T2ex effect of EuDOTA-(gly)4− in kidney tissues causes the image to become dark (white arrows). Reproduced with permission from Reference 40.