Table 5.
Comparison of schemes A and B for family-based meta-analysis for CurSmk at select variants
| Marker | Level | Type | N | MAC | MAC | Effect | StdErr | P | Stratified | Interaction |
|---|---|---|---|---|---|---|---|---|---|---|
| E=0 | E=0 | E=1 | E=0 | E=0 | E=0 | 2DF P | 2DF P | |||
| 2:48619812 (MAF=1.2%) | Meta | Scheme A | 4,479 | 12.8 | 1.0 | 7.8E-41 | 8.5E-40 | |||
| Meta | Scheme B | 3,160 | 0.6 | 2.7 | 0.83 | 0.63 | 0.89 | |||
| Cohort | FamHS | 3,160 | 77.7 | 13.7 | 0.6 | 2.6 | 0.83 | 0.60 | 0.89 | |
| Cohort | GENOA | 895 | 29.9 | <10 | 3.2 | 3.1 | 0.30 | |||
| Cohort | HERITAGE | 424 | 10.3 | <10 | 15.8 | 1.0 | 1.2E-54 | |||
|
| ||||||||||
| 6:142093034 (MAF=1.7%) | Meta | Scheme A | 12,798 | 4.7 | 0.5 | 3.8E-23 | 2.2E-22 | |||
| Meta | Scheme B | 10,342 | −0.1 | 1.0 | 0.89 | 0.47 | 0.61 | |||
| Cohort | ERF | 1,507 | 66.9 | 52.7 | 1.2 | 2.1 | 0.58 | 0.68 | 0.78 | |
| Cohort | FamHS | 3,160 | 140.3 | 25.2 | 0.2 | 1.6 | 0.88 | 0.98 | 0.89 | |
| Cohort | FHS | 5,675 | 141.8 | 63.0 | −0.5 | 1.5 | 0.74 | 0.47 | 0.5 | |
| Cohort | GENOA | 895 | 43.8 | <10 | −4.0 | 2.6 | 0.12 | 0.15 | 0.12 | |
| Cohort | HERITAGE | 424 | 19.1 | <10 | −6.3 | 0.5 | 1.9E-33 | |||
| Cohort | HyperGEN | 1137 | 30.5 | <10 | 0.3 | 4.4 | 0.95 | |||
|
| ||||||||||
| 12:5679139 (MAF=1.3%) | Meta | Scheme A | 4,479 | 1.9 | 2.1 | 0.37 | 1.8E-09 | |||
| Meta | Scheme B | 3,160 | 4.1 | 2.8 | 0.15 | 5.0E-09 | 1.9E-11 | |||
| Cohort | FamHS | 3,160 | 84.1 | 12.5 | −4.1 | 2.8 | 0.14 | 6.3E-10 | 3.8E-12 | |
| Cohort | GENOA | 895 | 33.5 | <10 | 3.1 | 3.7 | 0.41 | 0.2 | 0.21 | |
| Cohort | HERITAGE | 424 | 10.5 | <10 | −3.6 | 4.8 | 0.46 | 0.59 | 2.4E-08 | |