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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Crit Care Med. 2016 Jul;44(7):e530–e543. doi: 10.1097/CCM.0000000000001562

Figure 3. Deficiency of Spred-2 modulates immune response during influenza virus infection.

Figure 3

(A) Protein levels of cytokines and chemokines in whole lungs from WT and Spred-2 KO mice at days 3 and 5 after influenza virus infection, determined by ELISA. (B) Flow cytometry analysis of lung macrophage (CD11b+F4/80+), neutrophil (Gr-1high), CD4+ T cell (CD3+CD4+), CD8+ T cell (CD3+CD8+), NK cell (CD3−NK1.1+), and NKT cell (CD3+NK1.1+) isolated from influenza challenged WT and Spred-2 KO mice at days 3 and 5.*p < 0.05, **p < 0.01 compared with WT mice. Data shown indicate mean ± SEM and are from a representative experiment of 3 independent experiments. Each point had 5 mice per group.