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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Gene. 2016 Apr 5;586(2):197–205. doi: 10.1016/j.gene.2016.03.058

Fig. 5.

Fig. 5

Cis-acting consensus sequences recognized by CNC and sMaf. (A) Alignment of the CRE, C-MARE, TRE, T-MARE, NF-E2, and ARE/EpRE motifs. De novo motifs revealed by ChIP-Seq studies (Nrf2, p45NF-E2, and Bach1) are shown below [modified data from (Hirotsu et al., 2012b; Warnatz et al., 2011; Fujita et al., 2013) are shown]. (B) Binding mode of Skn-1, CNC, Bach, and sMaf proteins. Although Skn-1 binds to DNA as a monomer (left box), CNC and Bach proteins bind to DNA as heterodimers with sMafs (right box). Although CNC-sMaf and Bach-sMaf heterodimers preferentially bind to CsMBE, sMaf homodimers preferentially bind to MARE. Asterisk: the exact binding sequences for Jun-sMaf and Fos-sMaf heterodimers have not yet been determined.