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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Cancer Res. 2016 May 6;76(12):3553–3561. doi: 10.1158/0008-5472.CAN-15-2104

Fig. 6. Proposed model for mode of action of vincristine in ALL cells.

Fig. 6

Cells in G1 phase are susceptible to death directly, whereas cells that have passed a putative “microtubule sensitivity checkpoint” in late G1/early S phase continue to cycle and die following mitotic arrest.