Table 1.
Demographic characteristics for participants with and without significant fibrosis.
| Background Characteristics (%) | Fibrosis
|
||
|---|---|---|---|
| Significant (n=258) | Not Significant (n=1221) | p-value | |
| Age, mean (SD) | 51.31 (7.25) | 45.11 (9.37) | <0.001 |
| WRAT-3 reading subtest, mean (SD) | 89.91 (16.34) | 92.38 (17.80) | 0.04 |
| Years of education, mean (SD) | 11.80 (2.68) | 12.55 (2.91) | <0.001 |
| HIV status, % | 217 (84) | 788 (64) | <0.001 |
| Race/Ethnicity | 0.04 | ||
| African American, non-Hispanic | 153 (60) | 794 (65) | |
| White, non-Hispanic | 34 (13) | 148 (12) | |
| Hispanic | 65 (25) | 227 (18) | |
| Other | 6 (2) | 52 (4) | |
| Annual household income ≤$12,000/year | 158 (61) | 518 (42) | <0.001 |
| Current depressive symptoms, CES-D ≥16 | 98 (38) | 352 (29) | 0.004 |
| Hepatitis C positive RNA, % | 164 (64) | 144 (12) | <0.001 |
| Recent antidepressant medication use | 46 (18) | 180 (15) | 0.21 |
| Recent alcohol use | 0.10 | ||
| Abstainer | 162 (63) | 679 (56) | |
| Not heavy | 56 (22) | 314 (26) | |
| Heavy | 40 (15) | 228 (18) | |
| Recent marijuana/hash use | 40 (15) | 214 (17) | 0.44 |
| Smoking status | <0.001 | ||
| Never | 36 (14) | 343 (28) | |
| Former | 137 (53) | 501 (41) | |
| Recent | 85 (33) | 377 (31) | |
| Recent Crack, cocaine, and/or heroin use | 22 (8) | 71 (6) | 0.10 |
| Diabetes | 71 (27) | 199 (16) | <0.001 |
| Hypertension | 135 (52) | 476 (39) | <0.001 |
| Body mass index | 28.17 (8.42) | 30.89 (8.31) | <0.001 |
| HIV Disease† | |||
| Nadir CD4 count, median (IQR) | 175.54 (130.77) | 225.51 (164.74) | <0.001 |
| CD4 Count | |||
| > 500 | 75 (34) | 432 (55) | <0.001 |
| ≥ 200 and < 500 | 95 (44) | 270 (34) | |
| < 200 | 47 (22) | 86 (11) | |
| Plasma HIV RNA | <0.001 | ||
| Undetectable | 92 (42) | 437 (55) | |
| < 10,000 | 73 (34) | 259 (33) | |
| ≥ 10,000 | 52 (24) | 92 (12) | |
| cART >95% compliance | 135 (62) | 501 (63) | 0.86 |
| APRI, median (IQR) | 1.34 (0.68) | 0.23 (0.14) | <0.001 |
Significant fibrosis=APRI values ≥0.5. Not Significant Fibrosis APRI values <0.50.
Includes HIV-infected women only. WRAT-3 = Wide Range Achievement Test Standard Score. CES-D Center for Epidemiological Studies Depression scale. “Current” refers to within the past week”; “Recent” refers to within 6 months of the most recent WIHS visit. “Former” refers to any previous use, but not in the past 6 months. cART = combination antiretroviral therapy; Heavy alcohol use = reflects >7 drinks per week or more than 4 drinks in one sitting. Undetectable=<48copies/ml. Diabetes= defined as having a self-reported diagnosis, a fasting glucose of over 125 mg/dL, or being on diabetic medications. Hypertension=defined as any indication of hypertension (systolic blood pressure ≥140, diastolic blood pressure ≥90, self-report, or use of antihypertensive medication.