Table 3. Independent contributions of HIV and HCV controlling for significant fibrosis by APRI on cognitive test performance.
Results from multivariable linear regression analyses of primary and secondary outcome measures.
| Cognitive Domains | n | Primary Predictors
|
|
|---|---|---|---|
| HIV-infection B (SE) |
Hepatitis C positive B (SE) |
||
| Primary Outcomes | |||
|
| |||
| Verbal Learning | 1467 | −1.34 (0.53)* | −0.02 (0.71) |
|
| |||
| HVLT: Trial 1 | 1467 | −1.46 (0.56)** | 0.10 (0.75) |
| HVLT: Total Trials 1–3 | 1467 | −1.23 (0.56)* | −0.13 (0.75) |
|
| |||
| Attention and Concentration | 1290 | −0.83 (0.44) | −0.50 (0.59) |
|
| |||
| Stroop Trial 1&2 | 1456 | −1.53 (0.64)* | −2.58 (0.86)** |
| Trail Making Test Part A | 1465 | −0.28 (0.58) | 0.73 (0.78) |
| LNS Attention | 1305 | −1.37 (0.63)* | −1.03 (0.84) |
|
| |||
| Executive Functions | 1223 | −0.06 (0.51) | −0.66 (0.50) |
|
| |||
| Stroop Trial 3 | 1407 | −0.32 (0.75) | −0.48 (0.73) |
| Trail Making Test Part B | 1427 | −0.07 (0.60) | −1.76 (0.81)* |
| LNS Working Memory | 1270 | 0.03 (0.67) | 0.43 (0.89) |
|
| |||
| Secondary Outcomes | |||
|
| |||
| Verbal Memory | 1467 | −1.45 (0.53)** | 0.94 (0.71) |
|
| |||
| HVLT: Delayed free recall | 1467 | −1.57 (0.56)** | 0.78 (0.79) |
| HVLT: Percent Retention | 1467 | −1.33 (0.58)* | 1.13 (0.77) |
|
| |||
| Psychomotor Speed | 1459 | −0.26 (0.56) | −0.28 (0.75) |
|
| |||
| Fluency | 1458 | 0.19 (0.49) | 0.46 (0.66) |
|
| |||
| Letter | 1460 | 0.36 (0.59) | 0.35 (0.79) |
| Semantic | 1458 | 0.07 (0.57) | 0.60 (0.76) |
|
| |||
| Fine Motor Skills | 1416 | 0.18 (0.59) | −0.30 (0.79) |
|
| |||
| Dominant hand | 1444 | 0.37 (0.60) | −0.60 (0.80) |
| Non-dominant hand | 1416 | −0.11 (0.63) | −0.12 (0.84) |
Note.
***
p<0.001;
**
p<0.01;
*
p<0.05.
HVLT = Hopkins Verbal Learning Test; LNS = Letter-Number Sequence; B = parameter estimates; SE= Standard Errors. All models are adjusted for APRI, site, marijuana use, crack, cocaine, and/or heroin use, smoking, heavy alcohol use, antidepressants, depressive symptoms, body mass index, hypertension, diabetes, income, and number of previous cognitive test exposure.