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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Dec 22;8(4):619–630. doi: 10.1002/wnan.1386

Figure 2.

Figure 2

(A) A schematic illustration of the 64Cu-NOTA-IONP(DOX)-cRGD nanoconjugates for combined tumor-targeted drug delivery and PET/MRI imaging. (B) A TEM image of IONP(DOX)-cRGD. (C) In vivo PET images of U87MG tumor-bearing mice 24 h after injection of different nanoconjugates. From left to right: targeted group (64Cu-NOTA-IONP-cRGD), non-targeted group (64Cu-NOTA-IONP) and blocking group. Tumors were marked by yellow arrow-heads. Reprinted with permission from [41].