Table 3.
Multivariable Cox Analyses on Survival Models in Validation Set (N=79)
| Multivariable Cox Regression Model | Overall Survival | Recurrence-Free Survival | |||||
|---|---|---|---|---|---|---|---|
| Parameter | Level | HR | 95% CI | P-value | HR | 95% CI | P-value |
| CD74 Tumor Intensity | Positive | 0.27 | 0.14, 0.51 | <0.001 | 0.41 | 0.22, 0.76 | 0.005 |
| MIF Tumor Intensity | Positive | 3.02 | 1.16, 7.83 | 0.02 | 3.60 | 1.57, 8.26 | 0.003 |
| Breslow Thickness | 0–1 | ---- | ---- | ---- | ---- | ---- | ---- |
| >1–2 | 0.81 | 0.31, 2.11 | 0.66 | 0.73 | 0.29, 1.84 | 0.51 | |
| >2–4 | 0.99 | 0.44, 2.25 | 0.99 | 0.61 | 0.27, 1.39 | 0.24 | |
| >4 | 1.12 | 0.48, 2.57 | 0.80 | 1.02 | 0.47, 2.19 | 0.96 | |
| Positive Lymph Nodes | 0–1 | ---- | ---- | ---- | ---- | ---- | ---- |
| 2–3 | 1.24 | 0.49, 3.09 | 0.65 | 0.74 | 0.31, 1.77 | 0.50 | |
| ≥4 | 1.46 | 0.68, 3.14 | 0.37 | 1.26 | 0.62, 2.55 | 0.52 | |
| Age at Surgery | Continuous, Per Year | 1.01 | 0.99, 1.03 | 0.47 | 1.00 | 0.99, 1.02 | 0.81 |
| Gender | Male | 1.24 | 0.68, 2.29 | 0.48 | 1.49 | 0.79, 2.80 | 0.22 |
HR: Hazard Ratio; CI: Confidence Interval