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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Nature. 2016 May 18;534(7607):347–351. doi: 10.1038/nature17964

Extended Data Figure 5. Improved resolution for structures determined in nanodisc.

Extended Data Figure 5

Comparison of density maps (blue mesh) determined from nanodisc- and amphipol-stabilized TRPV1 at various regions of the channel facing the lipid bilayer or at the bilayer surface. Refined atomic models (gold, nanodisc; grey, amphipol) are fit to corresponding densities. Side chain densities were significantly improved in nanodisc-stabilized TRPV1-DkTx/RTX structure (a, b), and notable improvement was also seen for unliganded (c, d) and capsazepine-bound (e, f) channels in nanodisc.