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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Nature. 2016 May 18;534(7607):347–351. doi: 10.1038/nature17964

Extended Data Figure 7. Categories of lipid densities observed in TRPV1 structures.

Extended Data Figure 7

a, Two continuous layers of density (blue) contributed by lipid head groups of bilayer within nanodisc are shown for apo channel (left) and channel in complex with RTX/DkTx (right). b, Atomic model of annular lipids could be built into well resolved densities (blue mesh) surrounding the channel protein. DkTx is shown as ribbon diagram (pink). Top-down views show distribution of resolved annular lipids (blue) in inter-subunit crevices at the outer leaflet of the membrane. c, Well-resolved densities (blue mesh) in the structures representing a phosphatidylcholine molecule (left) and a phosphatidylinositol molecule (right). Transmembrane helices of TRPV1 close to the binding site are also shown as ribbon diagrams (grey).