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. Author manuscript; available in PMC: 2016 Nov 18.
Published in final edited form as: Nature. 2016 May 18;534(7607):347–351. doi: 10.1038/nature17964

Figure 5. Structural rearrangements associated with vanilloid binding.

Figure 5

a, Ribbon diagrams depicting relative locations of S4, S4–S5 linker, S6 and TRP domain helices in the presence of phosphatidylinositol (blue, left), resiniferatoxin (orange, middle), or capsazepine (gold, right). Vanillyl ring of RTX uniquely stabilizes interaction between Arg557 and Glu570 to facilitate movement of the S4–S5 linker away from the central axis of the channel (indicated by red arrows), thereby facilitating opening of the lower gate through coupled movements (indicated by black arrows).