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. 2016 Jun 17;7:171. doi: 10.3389/fphar.2016.00171

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Copyright © 2016 Steiner, Harrer and Himly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustration of IgE-mediated cross-linking. Upon binding of the hapten-carrier complex to the drug-specific IgE captured on high affinity IgE receptor FcεRI, basophils react by degranulation and mediator release. CD63 is transferred from the vesicle to the plasma membrane and CD203c is upregulated, thus both serve as activation markers. (B) Flow cytometry dot plots of typical activation patterns for CD63 and CD203c; CCR3, basophil identification marker; PE, phycoerthrin label; FITC, fluorescein label; PE-Dy647, tandem label.