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. 2016 Jun 17;7:238. doi: 10.3389/fimmu.2016.00238

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Copyright © 2016 Subbian, Koo, Tsenova, Khetani, Zeldis, Fallows and Kaplan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bacillary load in Mtb-infected mouse lungs with or without CC-11050 and/or INH treatment. (A) Bacterial CFUs at various time points in different treatment groups. Treatment was started at 14 days postinfection. *P = 0.07 between INH (triangle) and INH plus CC-11050-treated groups (diamond) (n = 6 per group per time point). (B) Individual data points at 112 days. One animal out of six from each of INH or INH plus CC-11050-treated groups had unusual CFU pattern that can be an outlier or due to technical error. Excluding these two samples from the analysis led to a significant difference in lung CFUs at 112 days postinfection between the two treatment groups (P = 0.02; n = 5 per group).