Figure 2.

Enzyme regulation-based strategy. Flow chart of transcriptome analysis to verify the quality and potential of the suggested genes for new anti-fungal therapeutic strategies. Starting with transcriptome data two different sample groups were defined: condition X marking the specific experimental significant genotype/sample type and a group of background samples. The comparison results in a list of differential expressed genes in “condition X” which are considered to be important in the specific condition. Those differential expressed genes can then be mapped on the list of potential targets resulting from the scoring and filtering procedure. Those genes aligning with the target list is filtered regarding up-regulated genes (URGs) which are considered as promising targets for knockout and thereby as targets for new therapeutic strategies.