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. 2016 Jun 17;3:22. doi: 10.3389/fmolb.2016.00022

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Copyright © 2016 Kaltdorf, Srivastava, Gupta, Liang, Binder, Dietl, Meir, Haas, Osherov, Krappmann and Dandekar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic model of A. fumigatus. This figure illustrates the metabolic web considered, focusing on primary metabolism. Top: Shown are reactions, metabolites and enzymes (left) and modes calculated (right). Below major pathways modeled are given together with the number and examples of identified promising antibiotic target structures. Details are found in Supplementary Material File 19 together with input files, stoichiometric matrix, calculated elementary modes, and flux values for optimal growth and biofilm condition.