Table 2.
Metabolic gene expression under iron deficiency, invasion initiation, and hypoxia compared to controla.
| Iron deficiency | In vivo | Hypoxia adaptation | Pathway | Annotation | |
|---|---|---|---|---|---|
| Sup6 | |||||
| AFUA_3G04210 | 1.052 | −1.058 | −1.474 | FA | Fatty acid synthase alpha subunit FasA |
| AFUA_3G04220 | 1.153 | −1.971 | n.s. | FA | Fatty acid synthase beta subunit |
| AFUA_3G09290 | −0.706 | −0.719 | 1.479 | AA | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent |
| AFUA_3G06830 | n.s. | −1.684 | 0.945 | AA | Aspartate-semialdehyde dehydrogenase |
| AFUA_1G14570 | n.s. | 1.042 | −2.718 | AA | Phosphoribosyl-AMP cyclohydrolase |
| AFUA_4G06460 | n.s. | 2.834 | n.s. | AA | Pentafunctional AROM polypeptide |
| AFUA_3G14490 | n.s. | −1.401 | −1.574 | AA | Ketol-acid reductoisomerase |
| AFUA_5G05590 | n.s. | −1.060 | 1.703 | AA | Aspartokinase |
| AFUA_5G05820 | n.s. | −2.065 | 1.107 | AA | Homoserine kinase |
| AFUA_6G12400 | n.s. | −0.031 | −1.568 | SUC | 1,3-beta-glucan synthase catalytic subunit FksP |
| Sup2 | |||||
| AFUA_6G11390 | −0.926 | 0.459 | −2.196 | 1,3-beta-glucanosyltransferase Gel2 | |
| AFUA_3G11070 | 0.987 | −4.248 | n.s. | GLU | Pyruvate decarboxylase PdcA |
| AFUA_2G10740 | n.s. | −1.164 | n.s. | VIT | Thiamin biosynthesis protein (Thi-4) |
| AFUA_5G12190 | n.s. | −4.310 | −0.817 | Transcription initiation factor subunit (TAF30) | |
| AFUA_4G09660 | n.s. | 1.849 | n.s. | Secretory component protein shr3 | |
| AFUA_6G12400 | n.s. | −0.031 | −1.568 | SUC | 1,3-beta-glucan synthase catalytic subunit FksP |
| AFUA_1G06700 | n.s. | −1.705 | n.s. | Metacaspase CasA | |
| AFUA_3G14140 | 0.367 | −1.273 | −1.262 | Metacaspase CasB | |
| AFUA_4G13340 | n.s. | −0.008 | −1.412 | DUF907 domain protein | |
| AFUA_2G17650 | −0.523 | 2.921 | −2.795 | DUF907 domain protein | |
| AFUA_2G17300 | n.s. | 4.050 | 1.057 | GSH | Glutathione S-transferase |
| AFUA_2G09040 | n.s. | 1.360 | 1.053 | Vacuolar transporter chaperone (Vtc4) | |
| AFUA_2G04010 | n.s. | −1.125 | 1.182 | SUC | Alpha,alpha-trehalose-phosphate synthase subunit |
| ESSENTIAL GENES | |||||
| AFUA_3G14440 | 0.916 | −1.174 | n.s. | Cytochrome c oxidase family protein | |
| AFUA_4G10480 | n.s. | −2.375 | 1.812 | Mitochondrial large ribosomal subunit protein L30 | |
| logFC: -1 |  |
1 | |||
Only genes are listed that resulted from two ranking functions (RhumPDB + Expression, Supplementary Table 14; DegreeRank + BetweennessRank, Supplementary Table 10) and additionally show a high logarithmic fold change of >1.0 in their expression in at least one of the included datasets under consideration of only entries with a p < 0.05. Up-regulated genes are colored in varying shades of red to illustrate their specific expression change. Down-regulated genes are colored in shades of green, with increasing intensity toward negative regulation. The Datasets were taken from: [McDonagh et al., 2008 (1); Schrettl et al., 2010 (2); Willger et al., 2008 (3)]. Pathway abbreviations: FA, fatty acid metabolism; AA, amino acid metabolism; SUC, sugar modifications; GSH, glutathione metabolism; GLU, gluconeogenesis.