Table 4.
Top Targets from protein-protein interaction-based targeting of metabolisma.
| Iron deficiency | In vivo | Hypoxia adaptation | Pathway | Annotation | |
|---|---|---|---|---|---|
| Sup14 | |||||
| AFUA_3G04210 | 1.052 | −1.058 | −1.474 | FA | Fatty acid synthase alpha subunit FasA |
| AFUA_3G04220 | 1.153 | −1.971 | n.s. | FA | Fatty acid synthase beta subunit |
| AFUA_3G09290 | −0.706 | −0.719 | 1.479 | AA | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent |
| AFUA_1G14570 | n.s. | 1.042 | −2.718 | AA | Phosphoribosyl-AMP cyclohydrolase |
| AFUA_4G06460 | n.s. | 2.834 | n.s. | AA | Pentafunctional AROM polypeptide |
| AFUA_5G05590 | n.s. | −1.060 | 1.703 | AA | Aspartokinase |
| AFUA_5G05820 | n.s. | −2.065 | 1.107 | AA | Homoserine kinase |
| Sup10 | |||||
| AFUA_4G09660 | n.s. | 1.849 | n.s. | Secretory component protein shr3 | |
| AFUA_2G17650 | −0.523 | 2.921 | −2.795 | DUF907 domain protein | |
| AFUA_2G17300 | n.s. | 4.050 | 1.057 | GSH | Glutathione S-transferase |
| AFUA_2G09040 | n.s. | 1.360 | 1.053 | SUC | Vacuolar transporter chaperone (Vtc4) |
| AFUA_2G04010 | n.s. | −1.125 | 1.182 | Alpha, alpha-trehalose-phosphate synthase subunit | |
| ESSENTIAL GENES | |||||
| AFUA_3G14440 | 0.916 | −1.174 | n.s. | Cytochrome c oxidase family protein | |
| AFUA_4G10480 | n.s. | −2.375 | 1.812 | Mitochondrial large ribosomal subunit protein L30 | |
| logFC: -1 |  |
1 | |||
a
Results of comparison of orthology results and transcriptomic results in consideration of metabolic function. Only differentially expressed genes with a confidence p < 0.05 are shown. Up-regulated genes are colored in varying shades of red to illustrate their specific expression change. The Datasets were taken from: [McDonagh et al., 2008 (1); Schrettl et al., 2010 (2); Willger et al., 2008 (3)]. Pathway abbreviations: FA, fatty acid metabolism; AA, amino acid metabolism; SUC, sugar modifications; GSH, glutathione metabolism; GLU, gluconeogenesis.