Table 1.
Baseline demographics and disease activity measures by disease pattern
| Demographics and disease activity indices | Whole cohort | 2001–04 | 2005–06 | 2007–08 | 2009–11 | P-valuea |
|---|---|---|---|---|---|---|
| Total, n | 1066 | 285 | 265 | 306 | 210 | - |
| Age, median (IQR), years | 7.74 (3.46–11.8) | 7.8 (4–11.7) | 8.2 (3.5–11.9) | 8.76 (3.6–11.9) | 6.34 (2.7–11.4) | 0.1 |
| Female, n (%) | 698 (65) | 186 (65) | 174 (65.4) | 198 (64.5) | 140 (66.7) | 0.72 |
| Ethnicity, n (%), White, Other | 960 (91) | 263 (92.3) | 249 (94) | 274 (89.5) | 174 (82.9) | 0.07 |
| 106 (9.9) | 22 (7.7) | 16 (6) | 32 (10.5) | 36 (17.1) | ||
| Active Joint Count, median (IQR) | 2 (1–5) | 2 (1–4) | 2 (1–6) | 2 (1–5) | 2 (1–5) | 0.82 |
| Limited Joint Count, median (IQR) | 1 (1–3) | 1 (1–3) | 1 (1–4) | 1 (0–3) | 1 (1–3) | 0.29 |
| Physician GA, median (IQR) | 29 (16–51) | 34.3 (19–60) | 33 (20–53) | 25 (14–45.5) | 25.5 (13–45) | 0.03 |
| Parent GE, median (IQR) | 21 (5–49) | 20 (5–50) | 24.5 (8–46.5) | 21 (4–51) | 25 (12–40) | 0.95 |
| ESR, median (IQR) | 21 (7–50) | 15 (6–44) | 26 (7–52) | 21 (7.5–51.5) | 23 (5–49) | 0.08 |
| Pain, median (IQR) | 30 (8–59) | 36.5 (10–65) | 36.5 (12–60) | 27 (6–54) | 29.5 (9.5–52.5) | 0.048 |
| CHAQ, median (IQR) | 0.6 (0.1–1.4) | 0.8 (0.1–1.5) | 0.9 (0.3–1.5) | 0.6 (0.1–1.4) | 0.6 (0.1–1.3) | 0.045 |
| JADAS, median (IQR), n | 10.75 (5.7–17.6), 424 | 10.8 (7–16.2), 135 | 12.1 (7.2–20.2), 113 | 9.3 (4.4–18.4), 103 | 10.4 (4–15.6), 73 | 0.60 |
| JADAS3-71, median (IQR), n | 9.3 (5–14.4), 553 | 9.4 (5.7–13.6), 190 | 10 (6.4–16.3), 148 | 8.6 (4.1–4.2), 128 | 8.6 (4–14.6), 87 | 0.35 |
aP-values compare time groups for each variable and are adjusted by hospital and disease pattern. CHAQ: Childhood Health Assessment Questionnaire; GA: global assessment; GE: global evaluation; IQR: interquartile range; JDAS: juvenile arthritis disease activity score.