Table 1. Reference studies for all 16 analyzed SNPs with the reported risk allele.
| SNP | Chromosome | Position[bp] | General population studies |
Case-control studies |
|||
|---|---|---|---|---|---|---|---|
| Study | Reportedrisk allele | Effect size | Reportingassociation | Not Reportingassociation | |||
| rs1091047-DCDC2 | 6 | 24295256 | Lind et al.8 | G | expl. variance = 0.64% | – | – |
| rs1419228-DCDC2 | 6 | 24178306 | Lind et al.8 | G | expl. variance = 0.87% | – | – |
| rs9467075-DCDC2# | 6 | 24205236 | Lind et al.8 | A | expl. variance = 0.35% | – | – |
| rs9467076-DCDC2# | 6 | 24209255 | Lind et al.8 | C | expl. variance = 0.34% | – | – |
| rs6922023-DCDC2 | 6 | 24348117 | Lind et al.8 | G | expl. variance = 0.40% | – | – |
| rs7765678-DCDC2 | 6 | 24330544 | Lind et al.8 | T | expl. variance = 0.45% | – | – |
| rs8037376-DYX1C1 | 15 | 55768321 | Paracchini et al.9 | C | −0.147 SD (spelling) per risk allele | – | – |
| rs8043049-DYX1C1# | 15 | 55777788 | Paracchini et al.9 | C | −0.163 SD (spelling) per risk allele | – | – |
| rs7174102-DYX1C1# | 15 | 55719687 | Paracchini et al.9 | T | −0.135 SD (spelling) per risk allele | – | – |
| rs8040756-DYX1C1 | 15 | 55798599 | Paracchini et al.9 | G | −0.196 SD (reading) per risk allele | – | – |
| rs2038137-KIAA0319 | 6 | 24645943 | Luciano et al.12; Paracchini et al.13 | G | 0.06 SD (reading) per copy of haplotype (rs4504469-rs2038137-rs2143340)12; Beta = −0.067 (adjusted reading values) per copy of haplotype (rs4504469-rs2038137-rs2143340)13 | Harold et al.19; Cope et al.20 | Couto et al.21; Scerri et al.27 |
| rs4504469-KIAA0319# | 6 | 24588884 | Luciano et al.12; Paracchini et al.13 | C | 0.06 SD (reading) per copy of haplotype (rs4504469-rs2038137-rs2143340)12; Beta = −0.003 (adjusted reading values) per copy of haplotype (rs4504469-rs6935076)13; Beta = −0.067 (adjusted reading values) per copy of haplotype (rs4504469-rs2038137-rs2143340)13 | Cope et al.20; Newbury et al.24; Becker et al.23 | Couto et al.21; Brkanac et al.22, Harold et al.19 |
| rs6935076-KIAA0319 | 6 | 24644322 | Luciano et al.12; Paracchini et al.13 | T | 0.06 SD (reading) per copy of haplotype (rs4504469-rs2038137-rs2143340)12; Beta = −0.003 (adjusted reading values) per copy of haplotype (rs4504469-rs6935076)13 | Cope et al.20; Couto et al.21 | Harold et al.19 |
| rs1842129-NKAIN2 | 6 | 124838090 | Luciano et al.11 | G | Not reported | – | – |
| rs1995402-ROBO1 | 3 | 79790407 | Bates et al.10 | A | Not reported | – | – |
| rs2143340-TDP2 | 6 | 24659071 | Luciano et al.12 ; Paracchini et al.13 | C | Expl. variance:1% (reading)12 ;Beta = −0.074 (adjusted reading values) per risk allele13; Beta = −0.067 (adjusted reading values) per copy of haplotype (rs4504469-rs2038137-rs2143340)13 | Newbury et al.24 | Cope et al.20; Couto et al.21, Scerri et al.27, Becker et al.23 |
Note that rs2038137 and rs4504469 were reported to associate as 3-marker-haplotype rs4504469-rs2038137-rs2143340 and rs4504469 as 2-marker-haplotype rs4504469-rs6935076 in a case-control study. SNP positions are based on HG19. Explained variances for SNPs identified by Lind et al.8 were calculated for a principal factor score computed from six reading and spelling related measures. For the other SNPs, phenotypes are given in brackets. Shown is the absolute value of the effect size as presented in the paper. SNPs with independent effects identified by pruning (R2 = 0.5) are bold, and SNPs without independent effects are marked with # and were tagged by the respective independent SNP shown above.