Table 2. Association statistics.
| SNP | Reported risk allele and accordance | Major homozygous genotype | Minor homozygous genotype | Allelic association | |||
|---|---|---|---|---|---|---|---|
| p | GRR | p | GRR | p | OR | ||
| rs1091047-DCDC2 | Major (acc.) | 0.062 | 1.34 (1.0–1.8) | 0.720 | 0.88 (0.5–1.7) | 0.085 | 0.78 (0.6–1.0) |
| rs1419228-DCDC2 | Minor (acc.) | 0.491 | 0.90 (0.7–1.2) | 0.051 | 1.77 (1.0–3.1) | 0.292 | 1.15 (0.9–1.5) |
| rs9467075-DCDC2# | Major | 0.892 | 1.02 (0.7–1.4) | 0.481 | 1.29 (0.6–2.6) | 0.990 | 1.00 (0.7–1.3) |
| rs9467076-DCDC2# | Minor (acc.) | 0.985 | 0.99 (0.7–1.4) | 0.130 | 1.79 (0.8–3.8) | 0.767 | 1.05 (0.8–1.4) |
| rs6922023-DCDC2 | Major (acc.) | 0.268 | 1.19 (0.9–1.6) | 0.186 | 0.61 (0.3–1.3) | 0.186 | 0.83 (0.6–1.1) |
| rs7765678-DCDC2 | Major (acc.) | 0.035* | 1.52 (1.0–2.2) | 0.178 | 0.37 (0.1–1.6) | 0.023* | 0.65 (0.5–0.9) |
| rs8037376-DYX1C1 | Minor (acc.) | 0.951 | 1.01 (0.8–1.3) | 0.314 | 1.21 (0.8–1.7) | 0.741 | 1.04 (0.8–1.3) |
| rs8043049-DYX1C1# | Major | 0.576 | 1.08 (0.8–1.4) | 0.494 | 1.13 (0.8–1.6) | 0.970 | 0.99 (0.8–1.2) |
| rs7174102-DYX1C1# | Minor | 0.594 | 1.08 (0.8–1.4) | 0.439 | 1.15 (0.8–1.6) | 0.989 | 1.00 (0.8–1.2) |
| rs8040756-DYX1C1 | Major (acc.) | 0.305 | 1.19 (0.9–1.7) | 0.701 | 1.17 (0.5–2.6) | 0.38 | 0.87 (0.6–1.2) |
| rs2038137-KIAA0319 | Major (acc.) | 0.036* | 1.35 (1.0–1.8) | 0.887 | 0.97 (0.7–1.4) | 0.132 | 0.85 (0.7–1.0) |
| rs4504469-KIAA0319# | Major (acc.) | 0.987 | 0.99 (0.8–1.3) | 0.562 | 0.90 (0.6–1.3) | 0.802 | 0.97 (0.8–1.2) |
| rs6935076-KIAA0319 | Minor (acc.) | 0.088 | 0.78 (0.6–1.0) | 0.036* | 1.46 (1.0–2.1) | 0.039* | 1.25 (1.0–1.5) |
| rs1842129-NKAIN2 | Major | 0.100 | 0.78 (0.6–1.0) | 0.845 | 1.04 (0.7–1.5) | 0.261 | 1.13 (0.9–1.4) |
| rs1995402-ROBO1 | Minor (acc.) | 0.680 | 0.94 (0.7–1.3) | 0.708 | 0.94 (0.7–1.3) | 0.977 | 1.01 (0.8–1.2) |
| rs2143340-TDP2 | Minor | 0.442 | 1.14 (0.8–1.6) | 0.665 | 0.84 (0.4–1.8) | 0.406 | 0.88 (0.7–1.2) |
Shown are the respective p-values and genetic relative risks (GRR) for the homozygous major allele genotype and the homozygous minor allele genotype. Allelic associations relate to the effect of the minor allele reported in Supplemental Table 7. Shown is also the accordance (acc.) of the reported risk allele from literature with the observed risk allele of our study. SNPs with independent effects identified by priority pruning (R2 = 0.5) are bold, and SNPs without independent effects are marked with # and were tagged by the respective independent SNP shown above.