Figure 2. Impact of IL-22 in the course of PbA infection.

Wt and Il22^−/− mice were infected with 1 × 10⁵PbA iRBC i.p.. The parasitemia was analysed at d6 p.i. (n_wt = 6;  = 6) (A). Wt and Il22^−/− mice were infected with 1000 sporozoites i.v. The parasite burden in the liver was determined 24 h after sporozoite infection by qPCR (n_wt = 5;  = 6) (B). Survival of PbA iRBC-infected wt and Il22^−/− mice were monitored during the course of infection (n_wt = 6;  = 6) (C). Wt mice were infected with 1 × 10⁵PbA iRBC i.p. and simultaneously treated with 20 μg αIL-22 or control IgG, subsequently the course of infection was monitored (n_wt = 5;  = 5) (D). ALT (E) and AST (F) levels in the plasma were analysed in the control groups and in PbA iRBC-infected wt and Il22^−/− mice at d6 p.i. (n_{wt naive} = 2; _naive = 2; n_{wt PbA d6} = 5; _{PbA d6} = 5). Depicted are the means ± SEM.