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. 2016 Jun 17;6:28188. doi: 10.1038/srep28188

Figure 3. Sensory neuron MyD88 contributes to CFA induced persistent inflammatory pain and CCI induced neuropathic pain in the late phase.

Figure 3

(A,B) Complete Freund’s adjuvant (CFA) induced persistent inflammatory pain, expressed as mechanical hyperalgesia (A) and allodynia (B, percentage of response to 0.16 g filament) in WT and MyD88 CKO mice. *P < 0.05, two-way ANOVA compared with WT; n = 5 mice/group. (C) CFA induced paw edema as indicated by paw volume. (D,E) Nerve injury (CCI) induced mechanical hyperalgesia (D) and allodynia (E), expressed as 50% paw withdrawal threshold (D) and frequency response to a von Frey filament stimulation (0.16 g, E) in WT and MyD88 CKO mice. *P < 0.05, **P < 0.01, two-way ANOVA compared with WT, n = 5~7 mice/group.