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. 2016 Jun 17;6:28140. doi: 10.1038/srep28140

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(A) Time course of the experiments. rIL-12 mixed with anti-IFN-γ antibody or non-immune IgG was injected into the vitreous at P12. The eyes were analyzed at P17. (B) Representative images of flat-mounted retinas in the OIR mice that were injected of rIL-12 with non-immune IgG or anti-IFN-γ antibody at P12. (C) The size of the avascular areas was significantly larger than that of the controls. (D) The size of neovascular tufts was significantly larger than that of the controls. ^*P < 0.05 compared to the controls injected with rIL-12 and non-immune IgG (n = 12 or 14/group). Scale bars: 500 μm.