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. 2016 Jun 17;6:28178. doi: 10.1038/srep28178

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Copyright © 2016, Macmillan Publishers Limited

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Phase contrast images of MPCCs treated for 18 days with a hypo- (A), normo- (B) and hyperglycemic (C) culture medium. Nile red (neutral lipids) staining of MPCCs treated for 18 days with a hypo- (D), normo- (E) and hyperglycemic (F) culture medium. Scale bars represent 400 μm. (G) Quantification of Nile Red staining in hepatocyte islands in MPCCs subjected to hypo-, normo- or hyperglycemic culture media for 10 or 18 days. (H) Levels of sterol regulatory element binding protein (SREBF1), carbohydrate response element binding protein (MLXIPL), fatty acid synthase (FASN), nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) and heme oxygenase 1 (HMOX1) mRNA transcripts in MPCCs treated with hypo- and hyperglycemic culture media for 10 or 18 days. Data is normalized to a normoglycemic control. Error bars represent SD. *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. Trends were observed in multiple hepatocyte donors.