Table 1.
Total numbers of myeloid diagnoses and de Novo diagnoses: HMRN Sept 2004 to Aug 2013.
| Diagnoses |
Males |
Females |
||||
|---|---|---|---|---|---|---|
| Malignancy (International Classification of Disease for Oncology 3rd Edition) | Total | Myeloid de novo (% of total) | Total | Myeloid de novo (% of total) | Total | Myeloid de novo (% of total) |
| All myeloid malignancies | 5231 | 4945 (94.5) | 2868 | 2691 (93.8) | 2363 | 2254 (95.4) |
| Acute myeloid leukaemia (AML) (9727, 9861, 9871, 9866, 9895, 9896, 9920) | 1411 | 1190 (84.3) | 769 | 631 (82.1) | 642 | 559 (87.1) |
| AML, not otherwise specified (9861) | 860 | 825 (95.9) | 475 | 452 (95.2) | 385 | 373 (96.9) |
| AML with myelodysplasia-related changes (9895) | 197 | 13 (6.6) | 121 | 7 (5.8) | 76 | 6 (7.9) |
| AML with NPM1 mutation (9861) | 104 | 104 (100.0) | 42 | 42 (100.0) | 62 | 62 (100.0) |
| Acute promyelocytic leukaemia (APL) (9866) | 91 | 91 (100.0) | 47 | 47 (100.0) | 44 | 44 (100.0) |
| AML, core binding factor (9871, 9896) | 64 | 64 (100.0) | 41 | 41 (100.0) | 23 | 23 (100.0) |
| AML, probable therapy related (9920) | 61 | 59 (96.7) | 28 | 27 (96.4) | 33 | 32 (97.0) |
| AML with MLL (11q23) (9897) | 25 | 25 (100.0) | 10 | 10 (100.0) | 15 | 15 (100.0) |
| Myelodysplastic syndromes (MDS) (9982–9986) | 1194 | 1188 (99.5) | 794 | 790 (99.5) | 400 | 398 (99.5) |
| Refractory cytopenia with multilineage dysplasia (RCMD) (9985) | 497 | 495 (99.6) | 364 | 362 (99.5) | 133 | 133 (100.0) |
| Refractory anaemia with excess blasts (RAEB) (9983) | 458 | 455 (99.3) | 291 | 290 (99.7) | 167 | 165 (98.8) |
| Refractory anaemia with ring sideroblasts (RARS) (9982) | 213 | 212 (99.5) | 135 | 134 (99.3) | 78 | 78 (100.0) |
| Myelodysplastic syndrome (5q-) (9986) | 26 | 26 (100.0) | 4 | 4 (100.0) | 22 | 22 (100.0) |
| Myeloproliferative neoplasms (MPN) (9741, 9875, 9950, 9961, 9962, 9964, 9975. 9875) | 2330 | 2296 (98.5) | 1118 | 1100 (98.4) | 1212 | 1196 (98.7) |
| Chronic MPNsa (9950, 9962, 9975) | 1819 | 1812 (99.6) | 820 | 815 (99.4) | 999 | 997 (99.8) |
| Chronic myeloid leukaemia (CML) (9875) | 318 | 316 (99.4) | 189 | 188 (99.5) | 129 | 128 (99.2) |
| Myelofibrosis (9961) | 165 | 140 (84.8) | 99 | 87 (87.9) | 66 | 53 (80.3) |
| Systemic mastocytosis (9741) | 26 | 26 (100.0) | 8 | 8 (100.0) | 18 | 18 (100.0) |
| MDS/MPN (9945, 9946, 9975, 9876) | 296 | 271 (91.6) | 187 | 170 (90.9) | 109 | 101 (92.7) |
| Chronic myelomonocytic leukaemia (CMML) (9945) | 239 | 221 (92.5) | 152 | 140 (92.1) | 87 | 81 (93.1) |
| MDS/MPN, unclassifiable (9975) | 30 | 24 (80.0) | 17 | 13 (76.5) | 13 | 11 (84.6) |
| Atypical chronic myeloid leukaemia (9876) | 23 | 22 (95.7) | 17 | 16 (94.1) | 6 | 6 (100.0) |
a
Polycythaemia vera, essential thrombocythaemia, MPNs unclassified.