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. 2016 Jun 3;197(1):208–221. doi: 10.4049/jimmunol.1501204

FIGURE 6.

FIGURE 6.

Inflammatory infiltrates are minimally elevated in Il27ra−/− mice. (A) Representative WT (left panels [×4 magnification]) or Il27ra−/− (right panels [×4 magnification]) kidneys, 1 and 3 wk after i.v. infection with 1.5 × 107 CFU C. parapsilosis. Kidney sections were stained with H&E. Scale bars, 200 μm. (B) Higher magnification (×40 magnification) of boxed areas from (A). Scale bars represent 20 μm. Red arrows indicate neutrophil infiltration. (C and D) Graphs display percentage of area of inflammation in the kidneys from mice 1 wk (C) or 3 wk (D) after i.v. infection with 1.5 × 107 CFU C. parapsilosis. ■, WT mice; ▲, Il27ra−/− mice. (E and F) Graphs display average acute (neutrophilic) and chronic (lymphocytic) clinical scores from the cortex and medulla of kidneys from mice 1 wk (E) or 3 wk (F) after i.v. infection with 1.5 × 107 CFU C. parapsilosis stained with H&E. Graphs are the cumulative result of two independent experiments. Each symbol represents the average score from cortex and medulla for an individual mouse.