Figure 3.
Dopamine release and uptake are attenuated by carboplatin treatment. (A) Representative example of a fitting curve used for modeling. The arrow indicates the point of stimulation. (B) [DA]p measured from each dosing group in each region. No regional differences in the striatum were found, but generalized release was sharply attenuated. (C) [DA]p averaged across all brain regions at each dose. (D) Vmax measured from each dosing group in each region. No significant difference in Vmax was found between regions. (E) Vmax averaged across all brain regions at each dose (*p < 0.5, ***p < 0.001, n = 5 rats per group).