Table 2.

2004 Cairo and Bishop criteria for Tumor Lysis Syndrome

Variable	Grade 0	Grade I	Grade II	Grade III	Grade IV	Grade V
Creatinine	None	1.5 X ULN	˃1.5–3.0 X ULN	˃3.0–6.0 X ULN	˃6.0 X ULN	Death
Cardiac arrhythmia	None	Intervention not indicated	Nonurgent medical intervention indicated	Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)	Life-threatening (e.g., arrhythmia associated with CHF, hypotension, syncope, shock)	Death
Seizures	None		One brief, generalized seizure; seizure(s) well controlled by anticonvulsants, or infrequent focal motor seizures not interfering with ADL	Seizures in which consciousness is altered; poorly controlled seizure disorder; with breakthrough generalized seizures despite medical intervention	Seizures of any kind which are prolonged, repetitive, or difficult to control (e.g., status epilepticus, intractable epilepsy)	Death

ADL activities of daily living, CHF congestive heart failure, ULN upper level of normal