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. Author manuscript; available in PMC: 2017 Jun 14.
Published in final edited form as: Cell Metab. 2016 Jun 14;23(6):1127–1139. doi: 10.1016/j.cmet.2016.05.006

Figure 2. CD38 regulates the age-related NAD+ decline.

Figure 2

(A) CD38 activity in liver, adipose tissue, spleen and skeletal muscle of aging mice (n=6 animals for each age, **p<0.01 versus 5 month old mice).

(B) CD38 activity in liver of 1 year old WT and CD38 KO litter mate mice (*p<0.05).

(C) Total liver NAD+ and NADH levels in WT and CD38KO mice during aging measured by mass spectroscopy (n=4 mice for each age, *p<0.05, **p<0.01 versus 5 month old mice).

(D) Total liver NAD+ and NADH levels in WT and CD38KO mice during aging measured by cycling assay (n=14 animals for each age, *p<0.05, **p<0.01 versus 5 month old mice).

(E) NAD+ levels in adipose tissue, spleen, and skeletal muscle of WT and CD38KO mice during aging (n=4 animals for each age, *p<0.05, **p<0.01 versus 5 month old mice).

All values are mean ± SEM.