TABLE 3.
Response to sunitinib in coculturesa
| Cell line sunitinib sensitivity category | ID | Su/Ve ratio | P value |
|---|---|---|---|
| Sensitive | T285 (n = 3) | 0.19 | 0.013 |
| T283 (n = 3) | 0.39 | 0.0019 | |
| T279 (n = 3) | 0.42 | 0.010 | |
| TG206 (n = 13) | 0.48 | 0.0005 | |
| TG250 (n = 3) | 0.51 | <0.0001 | |
| TG158 (n = 4) | 0.57 | 0.0047 | |
| T264 (n = 4) | 0.58 | 0.014 | |
| TG144 (n = 10) | 0.60 | 0.0002 | |
| TG185 (n = 4) | 0.61 | 0.0022 | |
| TG142 (n = 4) | 0.62 | 0.0014 | |
| TG191 (n = 8) | 0.67 | 0.027 | |
| TG143 (n = 3) | 0.67 | 0.037 | |
| TG180 (n = 10) | 0.73 | 0.0009 | |
| Resistant | T249 (n = 4) | 0.68 | 0.051 |
| TG26 (n = 2) | 0.69 | 0.095 | |
| TG169 (n = 8) | 0.70 | 0.17 | |
| TG127 (n = 10) | 0.76 | 0.10 | |
| PF22 (n = 4) | 0.77 | 0.14 | |
| T258 (n = 4) | 0.79 | 0.11 | |
| T241 (n = 6) | 0.84 | 0.15 | |
| TG194 (n = 4) | 0.85 | 0.17 | |
| T239 (n = 6) | 0.87 | 0.47 | |
| T256 (n = 4) | 0.88 | 0.27 | |
| T230 (n = 2) | 0.91 | 0.75 | |
| PF114 (n = 4) | 0.94 | 0.79 | |
| TG121 (n = 8) | 1.03 | 0.71 | |
| T255 (n = 4) | 1.09 | 0.80 |
a
List of cell lines evaluated for sunitinib sensitivity in coculture assays with EC. Cell lines are separated into categories of sensitive and resistant (based on P value) and ranked within each group based on the Su/Ve ratio (ratio of EC numbers in RCC cocultures in the presence of sunitinib or vehicle). Sunitinib-resistant cell lines are indicated with boldface characters.