TABLE 5.

FGF expression in sunitinib-resistant RCC primary cultures^a

GF or cytokine	RCC line
	TG26		TG127		PF22		T258		T241		PF114		T121
	R/S ratio	P value	R/S	P value	R/S	P value	R/S	P value	R/S	P value	R/S	P value	R/S	P value
FGF1					6.26	2.4 × 10−6	1.94	0.013	38.2	2.00 × 10−5	11.6	0.028
FGF2	3.03	0.010	3.48	0.0035	6.45	3.6 × 10−5					3.40	0.015
FGF5					9.89	0.0021			6.68	7.4 × 10−5
FGF7					44.8	0.0028
FGF10											2.34	0.040
FGF11							5.26	0.031
FGF13			28.4	0.0041	2.14	0.0044	4.79	0.0067					15.5	2.3 × 10−7
FGF18			4.8	0.036
FGF20							3.12	0.026
FGF22	2.57	0.0082
HGF	8.14	0.0082					16.7	2.9 × 10−5	4.16	0.02

^aR/S ratio, expression value of individual resistant line divided by the average of the expression values of all sensitive lines. There was no expression detected from FGF3, FGF4, FGF8, FGF14, FGF16, FGF17, FGF19, FGF21, and FGF23. There was no observable increase for FGF6, FGF9, FGF12, or IL-8. GF, growth factor.