TABLE 2 .
List of recently captured host cell genes present in Proboscivirus genomesi
| Gene/protein name | Size (aa) | Present in EEHV type(s) | % identity to orthologuea
|
Normal functional role in host | Other virus(es) in which found, % identity | |
|---|---|---|---|---|---|---|
| Loxodonta | Human | |||||
| vGCNT1 (E4) | 536 | All EEHVsb | 68 (58) | 58 (68) | Protein glycosyl | BoHV4 (γ), 52 (68) |
| vFUT9 (E47) | 387 | EEHV1A, -1B, -5 | 46 (91) | 41 (97) | Protein glycosyl | Mimiviruses |
| vOGT1 (E9A) | 414 | EEHV4A, -4B | 53 (74) | 50 (74) | Protein glycosyl | Nil |
| vECTL (E16D) | 185 | EEHV4A, -4B | 48 (56) | 39 (80) | NK cell receptor | MuHV8 (β), 31 (95); SMCMV (β); CrHV (γ); TorHV (α); ChHV(Scuta); cowpox and fowlpox viruses |
| vOX2-1c (E54) | 295 | EEHV1A, -1B, -5 | 83 (65) | 67 (81) | Cell-cell ligand, Ig-fam, two Ig domains, TM anchor (T-cell, MC-Mph) | EqHV5 (γ) E11, 74 (68); MuHV8 (β), 65 (72); KSHV (γ) U14, 42 (61); HHV6 (β) U85; EBV (γ); frog HV1; Yaba poxvirus |
| vOX2-2d (E25) | 260 | EEHV1A, -1B, -5 | 28 (68) | 30 (64) | Same as above, two Ig domain, TM anchor | EEHV1 E54, 32 (69); KSHV E14, 26 (88); HHV6 U85, 32 (38) |
| vOX2-3e (E24) | 176 | EEHV1A, -1B, -5 | 40 (39) | 42 (46) | Same as above, one Ig domain | EqHV5 E11, 39 (39); acidic C-term |
| vOX2-4f (E23) | 264 | EEHV1A, -1B | 30 (70) | 32 (69) | Same as above, two Ig domain, acidic C-term | EEHV1 E54, 32 (69); EqHV5 E11, 20 (70) |
| vOX2-Vg (EE22A) | 260 | EEHV5 | 34 (70) | 34 (68) | Same as above, two Ig domain, TM anchor | EEHV1 E54, 36 (71); EqHV5 E11, 36 (64); MuHV8 e127, 29 (75) |
| vOX2-Bh (E24B) | 132 | EEHV4A, -4B | 41 (65) | 40 (71) | Same as above, one Ig domain | EEHV1 E54, 38 (67); EqHV5 E11, 42 (65); EEHV5 EE22A, 38 (71) |
| vGPCR1 (δ1) (U51) | 405 | EEHV4 | 17 (51) (Mu) | Serotonin R; opioid R; CCR1; MCMV, swinepox | EqHV2 E1 17 (59); HCMV US28 16 (47); FeHV1 (α); HHV6 | |
| vGPCR1 (δ1) (U51) | 376 | EEHV1A, -1B, -5 | 20 (57) (Hu) | Atyp Chem R4 (T-cell, MC-Mph); CCR11, Angio RII | EqHV2 E1 28 (28); sheep, goat, fowlpox | |
| vGPCR2 (δ2) (E12) | 782 | EEHV4 | 18 (38) | Angiotensin RII, opioid R, CXCR1 somatostatin R | ||
| vGPCR2 (δ2) (E12) | 608 | EEHV1A, -1B, -5 | 23 (51) (Hu) | CCR2; CCR1, -4, -5, -6, -9 | MCMV M33, 21 (59); RCMV, HCMV, EqHV2, HTup | |
| vRAIP3 (δ3) (E3) | 315 | All EEHVs (incl EEHV4) | 22 (80) (Hu) | Retinoic acid-induced protein 3 | Multiple paralogues in 7xTM family, includes EEHV1 vGPCR3 to vGPCR8 | |
| vCXCL1 (E36A) | 105 | EEHV1A, -2, -5 | Missing third Cys | Chemokine ligand (inhibitory?) | Some cytomegaloviruses, roseoloviruses; some rhadinoviruses | |
| vCD48 (EE44A) | 222 | EEHV5 (-1A, -1B) (vIgFam) | 32 (84) | BLAST1, T-cell regulation | Some strains of EEHV1; SMCMV, OMCMV; EqHV2 (γ), poxviruses | |
| ORF-C (E34) | 1,898 | EEHV1A, -1B, -5 | 33 (10) | FAM186 repeats | ||
Amino acid identity (fractional length of protein with homology), both as percentages.
All EEHVs means EEHV1A, EEHV1B, EEHV4A, EEHV4B, EEHV5A, and EEHV6 at least.
Unspliced.
Exons 1, 2, and 3 of EEHV1.
Exons 4a, 4b, and 5 of EEHV1.
Exons 1, 2, and 5 of EEHV1.
Exons 1, 2, 3, and 4 of EEHV5.
Exons 1 and 2.
Abbreviations: incl, including; BLAST1, B-lymphocyte activation marker; Bo, bovine; Eq, equine; Hu, human; Mu, murine; MC-Mph, monocyte-macrophage; TM, transmembrane; Ig, immunoglobulin; term, terminal; MCMV, murine cytomegalovirus; SMCMV, squirrel monkey cytomegalovirus; CrHV, cricetid herpesvirus; TorHV, tortoise herpesvirus; ChHV, chimpanzee herpesvirus; FeHV1, feline herpesvirus 1; Angio, angiotensin; OMCMV, owl monkey cytomegalovirus; Atyp Chem, atypical chemokine; Htup, Herpesvirus tupaia.