Table 2.
NHL2 patient characteristics and outcomes by dose level
| Patient number | CAR+ T-cell dose | Disease histology | Patient age (years) | KPS at HCT | Pre-HSCT disease status | Deauville score24 before HSCT | Days to ANC ≥500 | Best response | Disease status at data lock | Time (months) to progression or last follow-up |
|---|---|---|---|---|---|---|---|---|---|---|
| 2-1 | 50 × 106 | MCL | 57 | 100 | CR1 | 1 | 10 | Continuing CR | Continuing CR | 14.1 |
| 2-2 | 50 × 106 | DLBCL | 71 | 90 | PR | 3 | 10 | CR | Progressed | 12.6 |
| 2-3 | 50 × 106 | DLBCL | 57 | 80 | CR2 | 1 | 10 | Continuing CR | Continuing CR | 12.4 |
| 2-4 | 200 × 106 | MCL | 63 | 100 | CR1 | 1 | 11 | Continuing CR | Continuing CR | 12.3 |
| 2-5 | 200 × 106 | MCL | 61 | 100 | CR1 | 1 | 11 | Continuing CR | Progressed | 6.4 |
| 2-6 | 200 × 106 | DLBCL | 67 | 100 | PR | 3 | 10 | CR | CR | 12.2 |
| 2-7 | 200 × 106 | MCL | 62 | 90 | CR1 | 1 | 12 | Continuing CR | Continuing CR | 12.3 |
| 2-8 | 200 × 106 | DLBCL | 23 | 90 | CR1 | 4 | 11 | Continuing CR | Continuing CR | 12.5 |