Figure 1.

IHC of paraffin-embedded prostate specimens. (A) The panel on the left shows VM, indicated by a red arrow (magnified in inset), which are tubule-like structures that contain luminal erythrocytes and are delimited by cells that are negative for CD34 staining (brown). The panel on the right shows endothelium-dependent vessels (one of which is indicated by a black arrow and magnified in the inset) that are positive for CD34 staining. Note that red blood cells can be seen in the lumens of both VM and endothelium-dependent vessels. (B) EphA2 in PCa shows mainly cytoplasmic staining. Different expression levels of EphA2 in VM-positive and VM-negative tumors from the two distinct PCa patient groups. (Original magnification ×400; bar: 10 µm; for insets, 2.5µm).