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PKC-alfal/delta, MEK1/2, ERK1/2 and JNK1/2 are inhibited in PLC/PRF/5 cells after treatment with metformin. After treatment with metformin phosphorylation of multiple protein kinases were inhibited in PLC/PRF/5 cells: (A) PKC-alfal, (B) PKC-delta, (C) MEK1/2 (pT292), (D) MEK1/2 (pT386), (E) ERK1/2 and (F) JNK1/2. Metformin was used at 200 uM and sorafenib at 4 uM.
