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Mechanisms involved in UBE2D3 downregulation-mediated changes in telomere homeostasis, cell cycle, cell apoptosis, and DNA damage repair. (a) The effect of knockdown UBE2D3 on telomere homeostasis. (b) The effects of knockdown UBE2D3 on cell cycle, cell apoptosis and double-strand breaks proteins. (c) The effects of knockdown UBE2D3 on the expressions of TRF2, CDC25C, ATM, ATR, p-ATM, p-ATR and γH2AX, 24 h after 2Gy, 4Gy irradiation.
