Figure 1.
Subcellular and tissue localization of the Thioredoxin superfamily network. In C. elegans, members of the thioredoxin superfamily network have a sub-cellular and tissue specific localization. Characterized proteins are located in specific compartments, such as M, mitochondria (TRX-2, TRXR-2),65 ER, endoplasmic reticulum (PDI-1,2,3,51652; ERO-156; DNJ-27,64 C14B9.2, Y49E10.4), N, nucleus and cytosol (TRX-167; TRX-363), or only in the cytosol (TRXR-177, PNG-169). Most of these proteins have a broad expression pattern (PDI-350,6118; DNJ-2764, TRXR-277, PNG-169). However, some exhibit a tissue-specific expression*. TRX-1 is found in the intestine, ASI and ASJ neurons,62,67 TRXR-1 is expressed in the pharynx, intestine and vulva,77 TRX-2 is located AIYL/R and ASEL neurons,65 PDI-1/PDI-2 are expressed in hypodermis119,120 and TRX-3 is only present in the intestine.63 The tissue expression pattern of ERO-1, C14B9.2 and Y49E10.4 are still unknown.