Fig 9. Enzyme-metabolite interaction network around redox cofactors.

Left: NADH; Right: NADP⁺. For reporter metabolites (circles), size indicates the enrichment score of a gene set and colour indicates the up/down direction of regulation. Brightness indicates uni-directionality of regulation. For enzymes (stars), colour indicates the up/down direction of regulation based on the log₂(fold change) scheme. (For full information on gene names, the interactive file S4 Network or the corresponding annotations in S1 Table, using the “Gene names (primary)” column, may be consulted.)