Table 2. Inhibition potencies of 1,2-diarylethylamines as monoamine transporter reuptake inhibitors.
| IC50 (μM) | |||
|---|---|---|---|
| Compound | DAT | NET | SERT |
| DPH | 1.99 (0.91) | 9.25 (0.97) | >10 μM |
| 2-MXP | 30.0 (0.81) | 35.2 (2.04) | >10 μM |
| 3-MXP | 0.587 (0.92) | 2.71 (0.95) | >10 μM |
| 4-MXP | 2.23 (0.96) | 22.5 (1.75) | 19.0 (1.12) |
| 2-Cl-DPH | 10.5 (0.65) | 27.1 (1.02) | >10 μM |
IC50 values shown in μM. Hill slopes shown in parenthesis. ND–IC50 values were not determined because compounds showed less than 50% inhibition of uptake at 10 μM during a preliminary screening.